海峡生命科学前沿论坛第135讲(2019.6.27)-Multiscale cell fate through lens of single cells


时         间:2019年6月27日上午9:00-1000

地         点:研院林学中心会议室301   


报   告   Qing  Nie Departments  of Developmental & Cell Biology and Mathematics NSF-Simons Center for  Multiscale Cell Fate ResearchUniversity  of California, Irvine

报告题目Multiscale  cell fate through lens of single cells


Cells  make fate decisions in response to dynamic environmental and pathological  stimuli as well as cell-to-cell communications.  Recent technological  breakthroughs have enabled to gather data in previously unthinkable quantities  at single cell level, starting to suggest that cell fate decision is much more  complex, dynamic, and stochastic than previously recognized. Multiscale  interactions, sometimes through cell-cell communications, play a critical role  in cell decision-making. Dissecting cellular dynamics emerging from molecular  and genomic scale in single-cell demands novel computational tools and  multiscale models. In this talk, through multiple biological examples we will  present our recent works to use single-cell RNA-seq data and spatial imaging  data to uncover new insights in development, regeneration, and cancers. We will  also present several new computational tools and mathematical modeling methods  that are required to study the complex and dynamic cell fate process through the  lens of single cells.

Short  Bio

Dr.  Qing Nie is a Chancellor’s Professor of Mathematics, Developmental and Cell  Biology, and Biomedical Engineering at University of California, Irvine. Dr. Nie  is the director of the new NSF-Simons  Center for Multiscale Cell Fate Research jointly  funded by NSF and the Simons Foundation – one of the four national centers on  mathematics of complex biological systems. In research, he uses systems biology  and data-driven methods to study complex biological systems with focuses on  single-cell analysis, multiscale modeling, cellular plasticity, stem cells,  embryonic development, and their applications to diseases. Dr. Nie has published  more than 140 research articles and served in many NIH and NSF review panels,  maintaining a well-funded interdisciplinary research program. In training, Dr.  Nie has supervised more than 40 postdoctoral fellows and PhD students, with  majority of them working in academic institutions. Dr. Nie is a fellow of the  America  Association for the Advancement of Science and  a fellow of American  Physical Society.